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PYRUVATE DEHYDROGENASE COMPLEX
Descriptors Found:
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DeCS
Descriptor
English
:
Pyruvate Dehydrogenase Complex
Descriptor
Spanish
:
Complejo Piruvato Deshidrogenasa
Descriptor
Portuguese
:
Complexo Piruvato Desidrogenase
Tree Number:
D05.500.562.625
D08.811.600.741
Definition
English
:
A multienzyme complex responsible for the formation of
ACETYL COENZYME A
from
pyruvate
. The enzyme components are
PYRUVATE
DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE.
Pyruvate dehydrogenase complex
is subject to three types of
control
: inhibited by acetyl-CoA and NADH; influenced by the
energy
state of the cell; and inhibited when a specific
serine
residue in the
pyruvate decarboxylase
is phosphorylated by ATP.
PYRUVATE
DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia
Biochemistry
and
Molecular Biology
, 3rd ed)
Entry Combination - descr/qualif
English
:
Pyruvate Dehydrogenase Complex
/
deficiency
use
Pyruvate Dehydrogenase Complex Deficiency Disease
History Note
English
:
74(73)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
12205
Unique Identifier:
D011768
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS